Estramustine disodium phosphate
Estramustine sodium phosphate
CAS: 52205-73-9
Molecular Formula: C23H33Cl2NNaO6P
Estramustine disodium phosphate - Names and Identifiers
| Name | Estramustine sodium phosphate |
| Synonyms | Estracyt NSC 89199 iumphosphate ESTRAMUSTINE PHOSPHATE SODIUM Estramustine sodium phosphate Estramustine Phosphate Sodium Estramustine disodium phosphate -(dihydrogenphosphate),disodiumsalt Estramustine phosphate disodium salt disodium (17beta)-3-{[bis(2-chloroethyl)carbamoyl]oxy}estra-1,3,5(10)-trien-17-yl phosphate (17-Beta)-Estra-1,3,5(10)-Triene-3,17-Diol 3-(Bis(2-Chloroethyl)Carbamate) 17-(Dihydrogenphosphate) Disodium Salt Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt |
| CAS | 52205-73-9 |
| EINECS | 257-735-7 |
| InChI | InChI=1/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30;;/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30);;/q;2*+1/p-2/t18-,19-,20+,21+,23+;;/m1../s1 |
Estramustine disodium phosphate - Physico-chemical Properties
| Molecular Formula | C23H33Cl2NNaO6P |
| Molar Mass | 544.38 |
| Boling Point | 661.2°C at 760 mmHg |
| Flash Point | 353.7°C |
| Solubility | H2O: soluble50mg/mL |
| Vapor Presure | 2.21E-18mmHg at 25°C |
| Storage Condition | Inert atmosphere,2-8°C |
| In vitro study | Estramustine phosphate sodium (1 µg/mL) treatment suppressed PC3 cell growth. Estramustine phosphate sodium (2 µg/mL) treatment significantly elevates phosphatidylserine eversion amount on PC3 cells. Estramustine phosphate sodium induces PC3 cell apoptosis. Estramustine phosphate sodium (2 µg/mL) treatment decreases MiR-31 level. Estramustine phosphate odium induces s prostate cancer cell line PC3 apoptosis through reducing miR-31. Estramustine phosphate sodium, a unique antitumour agent, is selectively taken up by prostate cells and exerts antineoplastic effects by interfering with microtubule of dynamics and by reducing plasma levels of testosterone. Estrone and estradiol, products of the metabolism of Estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels similar to those achieved after surgical castration. |
Estramustine disodium phosphate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 37 - Irritating to the respiratory system |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | KG7350000 |
| HS Code | 29242990 |
Estramustine disodium phosphate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.772 ml | 8.86 ml | 17.72 ml |
| 5 mM | 0.354 ml | 1.772 ml | 3.544 ml |
| 10 mM | 0.177 ml | 0.886 ml | 1.772 ml |
| 5 mM | 0.035 ml | 0.177 ml | 0.354 ml |
Last Update：2024-01-02 23:10:35
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